期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1783, 期 12, 页码 2255-2261出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2008.06.015
关键词
Tau; Calcineurin A subunit; Calcineurin B subunit; Calmodulin; Protein interaction; Tauopathy
资金
- National Nature Science Foundation of China
- Research Fund for Doctoral Program of Higher Education
- National Important Basic Research Project
Calcineurin, an important protein Ser/Thr phosphatase which acts on tau in vivo, is a heterodimer of a catalytic subunit, calcineurin A, and a regulatory subunit, calcineurin B, and is unique in being regulated by calmodulin. Here, we find that both Subunits of calcineurin bind tau, and calmodulin interferes with the association between calcineurin and tau. The domains of both subunits of calcineurin and tau involved in binding are mapped. We also investigate the functional consequences of the interactions between both Subunits of calcineurin, tau and calmodulin, and reveal the interactions affect dephosphorylation of tau by calcineurin and contribute to the balance of phosphorylation and dephosphorylation of tau in vivo. Our findings may be of potential significance in neuronal physiology and also in neurodegenerative disorders. They shed some light on how the interactions might control the phosphorylation state of tau under physiological conditions, and provide new insights into the treatment of tauopathies such as Alzheimer's disease. (C) 2008 Elsevier B.V. All rights reserved.
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