期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1864, 期 9, 页码 2697-2706出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2017.09.006
关键词
C. elegans; Aging; Metabolism; Forward genetics; QTL mapping; Gene x environment interaction
资金
- AMC PhD Scholarship
- ERC Starting grant [638290]
- VIDI grant from ZonMw [91715305]
- European Research Council (ERC) [638290] Funding Source: European Research Council (ERC)
The biological mechanisms of aging have been studied in depth and prominent findings in this field promote the development of new therapies for age-associated disorders. Various model organisms are used for research on aging; among these, the nematode Caenorhabditis elegans has been widely used and has provided valuable knowledge in determining the regulatory mechanisms driving the aging process. Many genes involved in lifespan regulation are associated with metabolic pathways and are influenced by genetic and environmental factors. In line with this, C. elegans provides a promising platform to study such gene by environment interactions, in either a reverse or forward genetics approach. In this review, we discuss longevity mechanisms related to metabolic networks that have been discovered in C. elegans. We also highlight the use of wild populations to study the complex genetic basis of natural variation for quantitative traits that mediate longevity.
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