期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 107, 期 2, 页码 337-354出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/S0022-1139(00)00378-X
关键词
phospholipid; glycolipid; (poly)cationic lipid; liposome; lipoplex; drug delivery; gene transfer
A shea review on fluorinated liposomes made from highly fluorinated double-chain phospho- or glyco-lipids as well as fluorinated lipoplexes, e.g. complexes made from highly fluorinated polycationic lipospermines and a gene, is presented. These systems display a number of interesting physico-chemical and biological properties which make them very attractive alternatives as drug or gene carrying, targeting and delivering devices. The properties of the fluorinated liposomes that are discussed include liposome formation and shelf-stability, membrane structure, thermotropism and permeability, encapsulation, release and stability in various media (serum, detergents), bioavailability and biodistribution, anti-MN activity. The properties of the fluorinated lipoplexes that are reported include lipoplex formation, stability, in vitro cell transfection in the presence of serum or of bile. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据