期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1842, 期 8, 页码 1208-1218出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2013.12.011
关键词
Oxidative stress; Nrf2-ARE pathway; Misfolded proteins; Neurodegenerative diseases
资金
- National Institute of Environmental Health Science (NIEHS) [ES10042, ES08089]
Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. (C) 2013 Published by Elsevier B.V.
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