期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1842, 期 10, 页码 1910-1922出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2014.03.011
关键词
SNP; ncRNA; miRNA; IncRNA; Genetic variant; Human disease
资金
- Netherlands Organisation for Scientific Research (NWO-VICI) [918.66.620]
- Coeliac Disease Consortium 2 (BSIK) [03009]
- Capes Foundation, Ministry of Education of Brazil [BEX0891-10-0]
- European Research Council (ERC) under the European Union [2012-322698]
- Dutch Multiple Sclerosis Foundation [11-752]
It has been found that the majority of disease-associated genetic variants identified by genome-wide association studies are located outside of protein-coding regions, where they seem to affect regions that control transcription (promoters, enhancers) and non-coding RNAs that also can influence gene expression. In this review, we focus on two classes of non-coding RNAs that are currently a major focus of interest: micro-RNAs and long non-coding RNAs. We describe their biogenesis, suggested mechanism of action, and discuss how these non-coding RNAs might be affected by disease-associated genetic alterations. The discovery of these alterations has already contributed to a better understanding of the etiopathology of human diseases and yielded insight into the function of these non-coding RNAs. We also provide an overview of available databases, bioinformatics tools, and high-throughput techniques that can be used to study the mechanism of action of individual non-coding RNAs. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.
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