期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1842, 期 8, 页码 1282-1294出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2013.09.007
关键词
Mitochondrial dysfunction; Mitochondria-targeted antioxidant; Neuroprotection; Oxidative stress; Parkinson's disease
资金
- National Institutes of Health [NS039958, NS074443, NS65167]
Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial dysfunction and oxidative stress have a central role in the dopaminergic neurodegeneration of Parkinson's disease. In this context, mitochondria-targeted therapies that improve mitochondrial function may have great promise in the prevention and treatment of Parkinson's disease. In this review, we discuss the recent developments in mitochondria-targeted antioxidants and their potential beneficial effects as a therapy for ameliorating mitochondrial dysfunction in Parkinson's disease. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. (C) 2013 Elsevier B.V. All rights reserved.
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