期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1842, 期 12, 页码 2610-2620出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2014.07.013
关键词
cAMP; Sperm capacitation; Soluble adenylylcyclase; Transmembrane adenylyl cyclase
资金
- NIH [R01-TW008662, R01 HD44044, HD038082]
- Agencia Nacional de Promocion Cientifica y Tecnologica de Argentina [PICT 2012-1175, PICT 2011-0540]
- National Research Council of Argentina [PIP 112-201101-00740]
Cyclic adenosine 3',5'-monophosphate (CAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types. Over the last decades, a wide body of literature addressed the different roles of cAMP in cell physiology, mainly in response to neurotransmitters and hormones, cAMP is synthesized by a wide variety of adenylyl cyclases that can generally be grouped in two types: transmembrane adenylyl cyclase and soluble adenylyl cyclases. In particular, several aspects of sperm physiology are regulated by CAMP produced by a single atypical adenylyl cyclase (Adcy10, aka sAC, SACY). The signature that identifies sAC among other ACs, is their direct stimulation by bicarbonate. The essential nature of cAMP in sperm function has been demonstrated using gain of function as well as loss of function approaches. This review unifies state of the art knowledge of the role of cAMP and those enzymes involved in cAMP signaling pathways required for the acquisition of fertilizing capacity of mammalian sperm. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease. (C) 2014 Elsevier B.V. All rights reserved.
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