期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1842, 期 3, 页码 358-369出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2013.05.011
关键词
Brown adipose tissue; White adipose tissue; Adipocyte progenitor; Beta3-adrenergic receptor
资金
- National Institutes of Health [RO1DK076629, RO1DK62292]
- Canadian Institutes of Health Research Doctoral Research Award [MDR-214349]
Adipose tissue plays an essential role in regulating energy balance through its metabolic, cellular and endocrine functions. Adipose tissue has been historically classified into anabolic white adipose tissue and catabolic brown adipose tissue. An explosion of new data, however, points to the remarkable heterogeneity among the cells types that can become adipocytes, as well as the inherent metabolic plasticity of mature cells. These data indicate that targeting cellular and metabolic plasticity of adipose tissue might provide new avenues for treatment of obesity-related diseases. This review will discuss the developmental origins of adipose tissue, the cellular complexity of adipose tissues, and the identification of progenitors that contribute to adipogenesis throughout development. We will touch upon the pathological remodeling of adipose tissue and discuss how our understanding of adipose tissue remodeling can uncover new therapeutic targets. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. (C) 2013 Published by Elsevier B.V.
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