期刊
INVESTIGATIVE RADIOLOGY
卷 36, 期 2, 页码 82-86出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00004424-200102000-00003
关键词
lanthanide DOTA-tetraamide derivatives; water exchange; pH-sensitive contrast agents
资金
- NCI NIH HHS [CA-84697] Funding Source: Medline
- NCRR NIH HHS [RR-02584] Funding Source: Medline
RATIONALE AND OBJECTIVES. Slow water exchange in Gd3+ complexes is generally considered detrimental to their use as MR contrast agents. The objective of this work was to demonstrate how this feature may serve as a useful template for the design of responsive NIR agents. METHODS. Lanthanide (Ln) complexes of two 1,4,7,10-tetraazacyclododecane-N,N', N ,N'''-tetraacetic acid (DOTA)-tetraamide phosphonate (1) and phosphonate ester (2) ligands were studied by multinuclear (H-1, C-13, P-31, and O-17) nuclear MR spectroscopy. RESULTS. The inner-sphere water lifetime in the Ln(2) complexes was much longer (tauM(298) = 0.8-1.3 ms) than in the corresponding Ln(1) complexes, This allowed direct detection of the bound-water molecule in europium(2) in water at 40 degrees C by H-1 nuclear MR. The water relaxivity of gadolinium(2) was independent of pH between 8.5 and 6.0, whereas the relaxivity of gadolinium(1) increased more than twofold in this pH range. CONCLUSIONS. T1-weighted images of phantoms containing gadolinium(1) at different pH values demonstrate the efficacy of this complex as a pH-sensitive MR contrast agent.
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