期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1832, 期 9, 页码 1371-1377出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2013.01.016
关键词
Angiogenesis; Cancer; Metastasis; Xenograft; Zebrafish
资金
- Ministero dell'Istruzione, Universita e Ricerca (MIUR, Centro IDET, FIRB project) [RBAP11H2R9 2011]
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [10396]
- Federazione Italiana per la Ricerca sul Cancro (FIRC)
Tumor/endothelial cell cross-talk plays a pivotal role in the growth, neovascularization and metastatic dissemination of human cancer. Recent observations have shown that the teleost zebrafish (Danio rerio) may represent a powerful experimental platform in cancer research. Various tumor models have been established in zebrafish adults, juveniles, and embryos and novel genetic tools and high resolution in vivo imaging techniques have been exploited. In particular, grafting of mammalian tumor cells in zebrafish embryo body may simulate early stages of tumor development neovascularization, and local invasion whereas the injection of cancer cells in the bloodstream of zebrafish embryo may allow the study of metastatic homing and colonization. This review focuses on the recent advances in tumor xenotransplantation in zebrafish embryo for the in vivo study of the cancer neovascularization, invasion and metastatic processes. This article is part of a Special Issue entitled: Animal Models of Disease. (C) 2013 Elsevier B.V. All rights reserved.
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