期刊
MICROBES AND INFECTION
卷 3, 期 2, 页码 99-107出版社
ELSEVIER
DOI: 10.1016/S1286-4579(00)01357-5
关键词
G protein; interleukin-12; tumor necrosis factor alpha; antigen-presenting cells; dendritic cells; monocytes; cholera toxin; pertussis toxin
G-protein-coupled receptors have long been known to play a critical role in the recruitment and migration of leukocytes to areas of inflammation. This review will focus, however, on emerging data that G-protein-coupled receptors can modulate cytokine production by antigen-presenting cells including interleukin-12 and tumor necrosis factor-alpha and may therefore play a significant role in the regulation of innate and acquired immunity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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