期刊
JOURNAL OF BIOMEDICAL OPTICS
卷 20, 期 1, 页码 -出版社
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.20.1.016019
关键词
oral-cavity illumination; internal illumination; deep brain imaging; photoacoustic computed tomography; optical fiber; anatomic imaging
资金
- National Institutes of Health [DP1 EB016986, R01 CA186567, R01 EB016963, R01 EB010049]
Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE).
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