期刊
JOURNAL OF VIROLOGY
卷 75, 期 4, 页码 1984-1989出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.4.1984-1989.2001
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资金
- NIAID NIH HHS [AI32027, R01 AI032027] Funding Source: Medline
Human parainfluenza virus type 3 (HPIV-3) is an airborne pathogen that infects the epithelial cells of the respiratory tract. In the present study we investigated the interaction of HPIV-3 with the type II alveolar human lung polarized epithelial A549 cells. Although HPIV-3 entry and budding were bidirectional from both the apical and the basolateral domains, HPIV-3 exhibited preferential entry and release from the epical pole. While disruption of the cellular actin microfilament and microtubule by cytochalasin D and nocodazole, respectively, had no effect on virus entry, disruption of the microtubule but not the microfilament inhibited HPIV-3 release.
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