期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1822, 期 9, 页码 1411-1420出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2012.02.010
关键词
Peroxisome; Acyl-CoA synthetase; Lipid metabolism; Fatty acid activation
资金
- NIH [NS037355, HD024061, DK007751]
Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group either a fatty acid or the acyl side chain of a steroid derivative be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed. This thioesterification, or activation, reaction, catalyzed by enzymes belonging to the acyl-CoA synthetase family, is thus central to cellular lipid metabolism. However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4. In this review, we briefly describe the primary peroxisomal lipid metabolic pathways in which fatty acyl-CoAs participate. Then, we examine the evidence for presence and functions of acyl-CoA synthetases in peroxisomes, much of which was obtained before the existence of multiple acyl-CoA synthetase isoenzymes was known. Finally, we discuss the role(s) of peroxisome-specific acyl-CoA synthetase isoforms in lipid metabolism. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease. (C) 2012 Elsevier B.V. All rights reserved.
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