期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1812, 期 8, 页码 982-994出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2010.12.015
关键词
Liver X receptors; Macrophage; Cholesterol, Inflammation; Innate immunity; Phagocytosis; Autoimmunity
资金
- Spanish CSIC [2008201078]
- Ministry of I + D MICINN [SAF2005-03270, 2008-00057]
- Ramon y Cajal
- La Caixa [BM05-228]
- Ramon Foundation
- Areces Foundation
The liver X receptors (LXR alpha and LXR beta) are members of the nuclear receptor family of transcription factors that play essential roles in the transcriptional control of lipid metabolism. LXRs are endogenously activated by modified forms of cholesterol known as oxysterols and control the expression of genes important for cholesterol uptake, efflux, transport, and excretion in multiple tissues. In addition to their role as cholesterol sensors, a number of studies have implicated LXRs in the modulation of innate and adaptive immune responses. Both through activation and repression mechanisms, LXRs regulate diverse aspects of inflammatory gene expression in macrophages. The ability of LXRs to coordinate metabolic and immune responses constitutes an attractive therapeutic target for the treatment of chronic inflammatory disorders. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据