期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1812, 期 11, 页码 1359-1370出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2011.08.005
关键词
Amyloid-beta; Oxidative stress; Antioxidant; Telomere; p53; DNA repair
资金
- NIH [AG028072, RR00163]
- Alzheimer Association [IIRG-09-92429]
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease affecting thousands of people in the world and effective treatment is still not available. Over two decades of intense research using AD postmortem brains, transgenic mouse and cell models of amyloid precursor protein and tau revealed that amyloid beta (A beta) and hyperphosphorylated tau are synergistically involved in triggering disease progression. Accumulating evidence also revealed that aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction initiate and contributes to the development and progression of the disease. The purpose of this article is to summarize the latest progress in aging and AD, with a special emphasis on the mitochondria, oxidative DNA damage including methods of its measurement. It also discusses the therapeutic approaches against oxidative DNA damage and treatment strategies in AD. (C) 2011 Elsevier B.V. All rights reserved.
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