期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1812, 期 4, 页码 514-519出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2011.01.009
关键词
O-GlcNAc; Lung cancer; Colon cancer; Immunohistochemistry
资金
- Fundamental Research Funds for the Central Universities [201013004]
- Specialized Research Fund for the Doctoral Program of Higher Education [20100132120012]
- National Basic Research Program of China (973 Program) [2003CB716402]
- National High-tech RD Program [2007AA09Z418, 2007AA091506]
O-GlcNAc is a monosaccharide attached to serine or threonine hydroxyl moieties on numerous nuclear and cytoplasmic proteins; O-GlcNAcylation is dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Although recent studies have shown that O-GlcNAcylation plays essential roles in breast cancer progression, it is also necessary to know whether O-GlcNAcylation is involved in other types of human cancer. In this study, O-GlcNAcylation levels and the expressions of OCT and OGA in human lung and colon cancer tissues were examined by immunohistochemistry analysis. We found that O-GlcNAcylation as well as OCT expression was significantly elevated in the cancer tissues compared with that in the corresponding adjacent tissues. Additionally, the roles of O-GlcNAcylation in the malignancy of lung and colon cancer were investigated in vitro. The results showed that O-GlcNAcylation markedly enhanced the anchorage-independent growth of lung and colon cancer cells; O-GlcNAcylation could also enhance lung and colon cancer invasion in a context-dependent manner. All together, this study suggests that O-GlcNAcylation might play important roles in lung and colon cancer formation and progression, and may be a valuable target for diagnosis and therapy of cancer. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
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