期刊
BRITISH JOURNAL OF CANCER
卷 84, 期 4, 页码 475-477出版社
NATURE PUBLISHING GROUP
DOI: 10.1054/bjoc.2000.1598
关键词
Ashkenazi Jews; colorectal cancer; BRCA1; BRCA2; 185delAG; 5382insC; 617delT; inherited predisposition
类别
It is presently unclear whether carriers of BRCA1 mutations have an increased risk for colorectal cancer (CRC). To gain insight into this issue, 225 unselected Ashkenazi Jewish CRC patients were tested for the presence of the three common Jewish BRCA1/2 germline mutations: 185delAG and 5382insC (BRCA1) and 6174delT (BRCA2). A total of four carriers was found (4/225, 1.78%). This frequency is similar to the estimated normal Ashkenazi population frequency, thus suggesting that these specific mutations do not contribute to CRC predisposition. (C) 2001 Cancer Research Campaign.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据