期刊
FEBS LETTERS
卷 489, 期 2-3, 页码 129-133出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02097-X
关键词
protein-tyrosine kinase; Syk; neuron-like differentiation; P19 embryonal carcinoma cell; ERK
Syk has been implicated in activated immunoreceptors to downstream signaling events in hematopoietic cells. Here rye report that Syk is expressed in neuron-like cells and involved in neuron-like differentiation of embryonal carcinoma P19 cells. Immunoblot, RT-PCR, and Northern analysis indicated that Syk is expressed in mouse brain, PC12 and P19 cells. In addition, Syk was found to he tyrosine phosphorylated during neuron-like differentiation of P19 cells, Furthermore, adenovirus-mediated overexpression of Syk induced supernumerary neurite formation and extracellular signal-regulated kinase (ERK) activation in P19 cells. These results suggest that Syk plays an important role in signaling steps leading to ERK activation in P19 cells. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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