期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1792, 期 8, 页码 746-756出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2009.06.004
关键词
TGF-beta; Fibrosis; Arthritis; Nephritis; Inflammatory bowel disease; Crohn's disease; Wound-healing; Myocarditis
资金
- Deutsche Forschungsgemeinschaft [Ki439/6, Ki439/7, Wo 460/14-1, 14-2]
- Interdisciplinary Center of Clinical Research Jena [FKZ 010405]
- Jena Center of Bioinformatics [FKZ0313652B]
- Interdisciplinary Center of Clinical Research Jena
The action of transforming-growth-factor (TGF)-beta following inflammatory responses is characterized by increased production of extracellular matrix (ECM) components, as well as mesenchymal cell proliferation, migration, and accumulation. Thus, TGF-beta is important for the induction of fibrosis often associated with chronic phases of inflammatory diseases. This common feature of TGF-related pathologies is observed in many different organs. Therefore, in addition to the description of the common TGF-beta-pathway, this review focuses on TGF-beta-related pathogenetic effects in different pathologies/organs, i.e., arthritis, diabetic nephropathy, colitis/Crohn's disease, radiation-induced fibrosis, and myrocarditis (including their similarities and dissimilarities). However, TGF-beta exhibits both exacerbating and ameliorating features, depending on the phase of disease and the site of action. Due to its central role in severe fibrotic diseases, TGF-beta nevertheless remains an attractive therapeutic target, if targeted locally and during the fibrotic phase of disease. (C) 2009 Elsevier B.V. All rights reserved.
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