期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1792, 期 4, 页码 380-391出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2009.02.010
关键词
Dog; Cat; Stem cell; Telomerase
资金
- Biotechnology and Biological Sciences Research Council [BB/F008848/1] Funding Source: Medline
- BBSRC [BB/F008848/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F008848/1] Funding Source: researchfish
The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and turnout genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems. (C) 2009 Elsevier B.V. All rights reserved.
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