Synthesis of pyrrolidine C-nucleosides via heck reaction

[GRAPHICS] A novel method for the synthesis of pyrrolidine C-nucleosides has keen developed, The key step of the synthesis is the palladium(0)-mediated coupling of a disubstituted N-protected 2-pyrroline and 5-iodouracil. C-Nucleoside 14 and its N-methyl derivative 15 can easily be convened to the corresponding phosphoramidite building blocks for DNA synthesis.