Three-component process for the synthesis of 2-amino-2-chromenes in aqueous media

The reaction of an aldehyde, malononitrile and a phenol in water at reflux in the presence of cetyltrimethylammonium chloride (CTAC1) as catalyst affords a one-pot synthesis of 2-amino-2-chromenes. (C) 2001 Elsevier Science Ltd. All rights reserved.