期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1864, 期 6, 页码 922-931出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2018.07.006
关键词
Platelet-activating factor; Oxidized phospholipids; PAF-AH
资金
- Japan Society for the Promotion of Science KAKENHI [17H05053]
- AMED [JP18gm0710002, JP18gm5910005]
- Grants-in-Aid for Scientific Research [17H05053] Funding Source: KAKEN
Platelet-activating factor acetylhydrolases (PAF-AHs) are unique members of the phospholipase A(2 )family that can hydrolyze the acetyl group of PAF, a signaling phospholipid that has roles in diverse (patho)physiological processes. Three types of PAF-AH have been identified in mammals, one plasma type and two intracellular types [PAF-AH (I) and PAF-AH (II)]. Plasma PAF-AH and PAF-AH (II) are monomeric enzymes that are structurally similar, while PAF-AH (I) is a multimeric enzyme with no homology to other PAF-AHs. PAF-AH (I) shows a strong preference for an acetyl group, whereas plasma PAF-AH and PAF-AH (II) also hydrolyze phospholipids with oxidatively modified fatty acids. Plasma PAF-AH has been implicated in several diseases including cardiovascular disease. PAF-AH (I) is required for spermatogenesis and is increasingly recognized as an oncogenic factor. PAF-AH (II) was recently shown to act as a bioactive lipid-producing enzyme in mast cells and thus could be a drug target for allergic diseases. This article is part of a Special Issue entitled Novel functions of phospholipase A2 Guest Editors: Makoto Murakami and Gerard Lambeau.
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