期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1841, 期 8, 页码 1049-1059出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2013.12.012
关键词
Phospholipid; Membrane; Protein-lipid interaction; Model membrane system; Lipid presentation; Lipid identity
资金
- Deutsche Forschungsgemeinschaft (DFG) [TRR83 TP18]
- German Federal Ministry of Education and Research (BMBF)
The cell membrane serves, at the same time, both as a barrier that segregates as well as a functional layer that facilitates selective communication. It is characterized as much by the complexity of its components as by the myriad of signaling process that it supports. And, herein lays the problems in its study and understanding of its behavior - it has a complex and dynamic nature that is further entangled by the fact that many events are both temporal and transient in their nature. Model membrane systems that bypass cellular complexity and compositional diversity have tremendously accelerated our understanding of the mechanisms and biological consequences of lipid-lipid and protein-lipid interactions. Concurrently, in some cases, the validity and applicability of model membrane systems are tarnished by inherent methodical limitations as well as undefined quality criteria. In this review we introduce membrane model systems widely used to study protein-lipid interactions in the context of key parameters of the membrane that govern lipid availability for peripheral membrane proteins. This article is part of a Special Issue entitled Tools to study lipid functions. (C) 2013 Elsevier B.V. All rights reserved.
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