期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 98, 期 4, 页码 1734-1739出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.041618298
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资金
- NCI NIH HHS [CA-47554] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During experiments to investigate the biochemistry of receptor-ligand binding in more detail, the kinetic parameters of the interaction were observed to alter dramatically in the presence of Zn2+ but not other divalent cations, The basis of this phenomenon is Zn2+-induced multimerization of the KIR molecules as demonstrated by BIAcore, analytical ultracentrifugation, and chemical cross-linking experiments. Zn2+-dependent multimerization of KIR may be critical for formation of the clusters of KIR and HLA-C molecules, the natural killer (NK) cell immune synapse, observed at the site of contact between the NK cell and target cell.
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