期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1831, 期 6, 页码 1124-1133出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2013.03.007
关键词
Autophagy; Lipid metabolism; Atherosclerosis; Macrophage; Lipoprotein
资金
- Canadian Institutes of Health Research
The incidence of diseases characterized by a dysregulation of lipid metabolism such as obesity, diabetes and atherosderosis is rising at alarming rates, driving research to uncover new therapies to manage dyslipidemias and resolve the metabolic syndrome conundrum. Autophagy and lipid homeostasis - both ancient cellular pathways - have seemingly co-evolved to share common regulatory elements, and autophagy has emerged as a prominent mechanism involved in the regulation of lipid metabolism. This review highlights recent findings on the role of autophagy in the regulation of cellular cholesterol homeostasis and lipoprotein metabolism, with special emphasis on macrophages. From modulation of inflammation to regulation of cellular cholesterol levels, a protective role for autophagy in atherosclerosis is emerging. The manipulation of autophagic activity represents a new possible therapeutic approach for the treatment complex metabolic disorders such as obesity and the metabolic syndrome. (C) 2013 Elsevier B.V. All rights reserved.
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