期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1831, 期 3, 页码 533-542出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2012.09.008
关键词
Phosphatidylethanolamine; Biosynthesis; Function; Trypanosoma brucei; Phospholipid
资金
- Swiss National Science Foundation [31003A-130815]
- Swiss National Science Foundation (SNF) [31003A_130815] Funding Source: Swiss National Science Foundation (SNF)
Phospholipids are not only major building blocks of biological membranes but fulfill a wide range of critical functions that are often widely unrecognized. In this review, we focus on phosphatidylethanolamine, a major glycerophospholipid class in eukaryotes and bacteria, which is involved in many unexpected biological processes. We describe (i) the ins, i.e. the substrate sources and biochemical reactions involved in phosphatidylethanolamine synthesis, and (ii) the outs, i.e. the different roles of phosphatidylethanolamine and its involvement in various cellular events. We discuss how the protozoan parasite, Ttypanosoma brucei, has contributed and may contribute in the future as eukaryotic model organism to our understanding of phosphatidylethanolamine homeostasis. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism. (C) 2012 Elsevier B.V. All rights reserved.
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