[123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa

Background: Impaired serotonin transmission has been implicated in the pathophysiology of eating disorders. We investigated the in vivo availability of brain serotonin transporters and dopamine transporters in bulimia nervosa patients. Methods: Approximately 24 hours after injection of [I-123]-2 beta -carbomethoxy-3 beta-(4-iodophenyl)tropane([I-123] beta -CIT), single photon emission computed tomography scans were performed in 10 medication-free, female bulimic patients and 10 age-matched healthy females. For quantification of brain serotonin transporter and dopamine transporter availability, a ratio of specific to non-specific [I-123] beta -CIT brain binding was used (V-3 = target region - cerebellum/cerebellum). Results: Drug-free bulimia nervosa patients showed a 17% reduced brain serotonin transporter availability in the hypothalamus and thalamus, as compared with healthy control subjects (2.4 +/- 0.4 vs. 2.9 +/- 0.4, p = .026), and a similar reduction in striatal dopamine transporter availability. There was a negative correlation of illness duration and serotonin transporter availability (r = -.65; p = .042) and a strong positive correlation between hypothalmic/thalamic and striatal V-3 (r = .80, p < .001). Conclusions: This first report of reduced [I-123] -CIT binding in a relatively small group of patients with bulimia nervosa suggests a reduced hypothalamic and thalamic serotonin transporter availability in bulimia, which is more pronounced with longer duration of illness. (C) 2001 Society of Biological Psychiatry.