期刊
GENOMICS
卷 72, 期 1, 页码 15-20出版社
ACADEMIC PRESS INC
DOI: 10.1006/geno.2000.6435
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资金
- NCRR NIH HHS [1 P41 RR03655] Funding Source: Medline
Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a number of groups. To investigate this region, 29 polymorphic markers were used to genotype a combined set of 233 families. These markers were ordered based upon the genetic data, supplemented by published genetic and physical maps. Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect. (C) 2001 Academic Press.
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