期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
卷 1517, 期 3, 页码 455-459出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-4781(00)00271-2
关键词
serpentine receptor; leukotriene; pertussis toxin; Xenopus laevis oocyte; MK-571
We report the identification of an EST encoding a murine cysteinyl leukotriene (mCysLT) receptor. LTD4, LTC4 and LTE4 but not LTB4 or various nucleotides activated Ca2+-evoked Cl- currents in mCysLT(1) expressing Xenopus laevis oocytes. The response to LTD4 was blocked by MK-571, reduced by pretreatment with pertussis toxin (PTX), and was partly dependent on extracellular Ca2+. The identified murine CysLT(1) receptor differs from the hCysLT(1) receptor with regard to PTX sensitivity, receptor-mediated Ca2+ influx, and antagonist sensitivity. (C) 2001 Elsevier Science B.V. All rights reserved.
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