期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1811, 期 11, 页码 800-806出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2011.04.009
关键词
Liquid chromatography/tandem mass spectrometry; Multiple reaction monitoring; Precursor ion scan; Dolichol; Polyprenol
资金
- NIH [GM-069338]
- Israel Science Foundation [30/07]
Across evolution, dolichols and polyprenols serve as sugar carriers in biosynthetic processes that include protein glycosylation and lipopolysaccharide biogenesis. Liquid chromatography coupled with electrospray ionization mass spectrometry offers a powerful tool for studying dolichols and polyprenols in their alcohol or glycan-modified forms in members of all three domains of life. In the following, recent examples of the how different versions of this analytical approach, namely reverse phase liquid chromatography-multiple reaction monitoring, normal phase liquid chromatography/tandem mass spectrometry and normal phase liquid chromatography-precursor ion scan detection have respectively served to address novel aspects of dolichol or polyprenol biology in Eukarya, Archaea and Bacteria. This article is part of a Special Issue entitled Lipodomics and Imaging Mass Spectrometry. (C) 2011 Elsevier B.V. All rights reserved.
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