Synthesis of the C8-deoxyguanosine adduct of the food mutagen IQ

[GRAPHICS] The C8-2'-deoxyguanosine adduct of the food mutagen 2-amino-3-methylimadazo[4,5-f]-quinoline (IQ) has been synthesized, The key step is a palladium catalyzed N-arylation of a suitably protected 8-bromo-2'-deoxygunaosine derivative.