期刊
FEBS LETTERS
卷 491, 期 1-2, 页码 21-25出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02085-3
关键词
cytomegalovirus; endothelium; ecto-ATPase; CD39; ecto-5 ' nucleotidase; CD73
We describe enhanced expression and enzymatic activity of ecto-ATPase and ecto-5' nucleotidase on CMV infected endothelial cells as compared to uninfected cells, These ectoenzymes play a major role in modulation of platelet activation and aggregation. Furthermore, adenosine has a modulatory effect upon inflammation. Addition of ATP, ADP or AMP to cultures of CMV infected or uninfected endothelial cells revealed increased turnover of AMP in CMV infected endothelial cells. in addition, the superoxide production by stimulated polymorphonuclear cells was inhibited in the presence of CMV infected endothelial cells as compared to uninfected cells, probably due to the enhanced activity of ecto-5'-nucleotidase and associated to production of adenosine. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据