期刊
TETRAHEDRON
卷 57, 期 9, 页码 1801-1812出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(00)01152-2
关键词
aziridines; beta-lactams; carbonylation; cobalt
The effect of ring substituents on the cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to beta -lactams has been investigated. A variety of aziridines with different substituents and stereochemistry has been synthesized and subjected to carbonylation. The ring expansion to beta -lactam takes place in the absence of an electron-withdrawing substituent and higher yields are always obtained for cis-aziridines. Moreover, the regioselectivity of the reaction is affected by the nature of substituents at ring carbon atoms. (C) 2001 Elsevier Science Ltd. All rights reserved.
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