期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1801, 期 3, 页码 215-221出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2009.09.006
关键词
Drosophila; Lipotoxicity; Model organism; Energy homeostasis; Lipometabolism
资金
- Max Planck Society
Looking back over the century long research career of the fruit fly, Drosophila melanogaster has frequently been in the scientific spotlight with respect to fundamental discoveries in biology. The last decade witnessed the increasing importance of the fly as a human disease model but studies on energy homeostasis and lipometabolism remain in their infancy. This perspective, addressing readers largely unfamiliar with the Drosophila model system, aims to highlight the starting points for which the fly could be employed to gain a deeper understanding of lipotoxicity and possibly contribute to strategies for the identification of novel drug targets relevant to type 2 diabetes mellitus and the metabolic syndrome. (C) 2009 Elsevier B.V. All rights reserved.
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