期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1791, 期 6, 页码 399-407出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2008.10.002
关键词
Lipid droplet; Biogenesis; Apolipoprotein B-100; Lipoprotein; Endoplasmic reticulum; Electron microscopy
资金
- Ministry of Education, Culture, Sports, Science and Technology of the Government of Japan
- Nitto Foundation
The cytoplasmic lipid droplet (CLD) and very low-density lipoprotein are generated from the lipid ester synthesized in the endoplasmic reticulum. The lipid ester deposited between the two membrane leaflets is supposed to bulge toward the cytoplasm to make a nascent CLD, but its size must be below the resolution limit of conventional techniques and the detectable CLD should only form after acquisition of additional lipid esters. The CLD is different from vesicular organelles in that the internal content is highly hydrophobic and the shape is invariably spherical. Due to its unique characteristics, quantitative discordance between the surface and the volume may occur in the growth and/or involution processes of the CLD. The possibility that these processes may give rise to the structural and functional diversities of the CLD is discussed. (C) 2008 Elsevier B.V. All rights reserved.
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