期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1791, 期 6, 页码 501-506出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2008.10.010
关键词
Glycerolipid; Phospholipid; Membrane; Lipid droplet; Lysophosphatidic acid; Diacylglycerol
资金
- NIH [DK56598]
- UNC CNRU [DK056350]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK056350, R01DK056598] Funding Source: NIH RePORTER
Four homologous isoforms of glycero 1-3-phosphate acyltransferase (GPAT), each the product of a separate gene, catalyze the synthesis of lysophosphatidic acid from glycerol-3-phosphate and long-chain acyl-CoA. This step initiates the synthesis of all the glycerolipids and evidence from gain-of-function and loss-of-function studies in mice and in cell culture strongly suggests that each isoform contributes to the synthesis of triacylglycerol. Much work remains to fully delineate the regulation of each GPAT isoform and its individual role in triacylglycerol synthesis. (C) 2008 Elsevier B.V. All rights reserved.
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