期刊
MATURITAS
卷 38, 期 1, 页码 95-100出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-5122(00)00195-X
关键词
Alzheimer's disease; amyloid and Tau protein; estrogen; menopause
资金
- NIA NIH HHS [AG15457] Funding Source: Medline
- NINDS NIH HHS [NS36111] Funding Source: Medline
Evidence is presented indicating a role for estrogen in the function and maintenance of the aging brain. Based on complementary data that estrogen regulates the function of the immune-brain barrier, the hypothesis is presented that estrogen contributes to brain homeostasis via regulation of microglial activation, enabling immune-privileged status in the brain. Diminished estrogen levels during the menopause compromise the immune-brain barrier fostering inflammatory processes in the brain. This has potentially lethal consequences for brain cells- and may contribute to brain pathologies such as Alzheimer's disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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