期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 51, 期 3, 页码 155-161出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0168-8227(00)00224-2
关键词
cholesterol; lipid peroxidation; Momordica charantia; rat; streptozotocin-induced diabetes; triglycerides
Momordica charantia (karela) is commonly used as an antidiabetic and antihyperglycemic agent in Asian, Oriental and Latin American countries. This study was undertaken to investigate the effects: of long term feeding (10 weeks) of M. charantia fruit extract on blood plasma and tissue lipid profiles in normal and streptozotocin (STZ)-induced Type 1 diabetic rats. The results show that there was a significant (P < 0.05) increase in plasma non-esterified cholesterol, triglycerides and phospholipids in STZ-induced diabetic rats, accompanied by a decrease in high density lipoprotein (HDL)-cholesterol. A moderate increase in plasma (LPO) product, malonedialdehyde (MDA). and about two-fold increase in kidney LPO was also observed in STZ-induced diabetic rats. The treatment of diabetic rats with M. charantia fruit extract over a 10-week period returned these levels close tio normal. In addition. karela juice also exhibited an inhibitory effect on membrane LPO under in vitro conditions. These results suggest that M. charantia fruit extract exhibits hypolipidemic as well as hypoglycemic effects in the STZ-induced diabetic rat. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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