期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1781, 期 9, 页码 563-570出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2008.05.008
关键词
lysophosphatidic acid; cardiovascular disease
资金
- NCRR NIH HHS [S10 RR024598, S10 RR024598-01] Funding Source: Medline
- NHLBI NIH HHS [R01 HL078663, R01 HL078663-04, R01 HL074219, R01 HL074219-05] Funding Source: Medline
- NIGMS NIH HHS [R01 GM050388-14, R01 GM050388, P20 GM103527] Funding Source: Medline
- CSRD VA [I01 CX001550] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [S10RR024598] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL078663, R01HL074219] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050388, P20GM103527] Funding Source: NIH RePORTER
- Veterans Affairs [I01CX001550] Funding Source: NIH RePORTER
The bioactive lipid mediator lysophosphatidic acid (LPA) exerts a range of effects oil the cardiovasculature that suggest a role in a variety of critical cardiovascular functions and clinically important cardiovascular diseases. LPA is an activator of platelets from a majority Of human donors identifying a possible role as a regulator of acute thrombosis and platelet function in atherogenesis and vascular injury responses. Of particular interest ill this context, LPA is an effective phenotypic modulator of vascular smooth muscle cells promoting the de-differentiation, proliferation and migration of these cells that are required for the development of intimal hyperplasia. Exogenous administration of LPA results ill acute and systemic changes in blood pressure in different animal species, suggesting a role for LPA in both normal blood pressure regulation and hypertension. Advances in our understanding of the molecular machinery responsible for the synthesis, actions and inactivation of LPA now promise to provide the tools required to define the role of LPA in cardiovascular physiology and disease. In this review we discuss aspects of LPA signaling in the cardiovasculature focusing oil recent advances and attempting to highlight presently unresolved issues and Promising avenues for further investigation.
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