期刊
ACTA PAEDIATRICA
卷 90, 期 3, 页码 323-327出版社
WILEY
DOI: 10.1080/080352501300067712
关键词
antifungal susceptibility testing; Malassezia pachydermatis; molecular typing; nosocomial fungaemia
类别
Malassezia pachydermatis, a non-obligatory lipophilic yeast, has occasionally been implicated in nosocomial fungaemias. This study investigated a cluster of eight cases of M. pachydermatis infection and colonization in a neonatal intensive care unit over a 6 mo period. All patients were preterm with very low birthweight and suffered from various underlying diseases. Prolonged use of indwelling catheters and parenteral lipid formulations were important predisposing factors for their infection. All M. pachydermatis strains were susceptible to amphotericin B, flucunazole and itraconazole but resistant against flucytosine. Conclusion: Molecular typing by random amplification of polymorphic DNA showed distinct banding profiles for each blood isolate. Since no epidemiological association among the strains could be shown, the reason for this cluster of nosocomial fungaemias remains unclear.
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