期刊
NEUROBIOLOGY OF AGING
卷 22, 期 2, 页码 265-272出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0197-4580(00)00234-7
关键词
aging; choroid plexus; cytochrome c oxidase; deficient; neurons; succinate dehydrogenase
The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c oxidase-deficient cells in both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that these cells contribute to the cell death and dysfunction in CNS aging. (C) 2001 Elsevier Science Inc. All rights reserved.
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