期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 11, 期 4, 页码 531-554出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2015.2090
关键词
Nano-Photosensitizers; Photodynamic Therapy; Cancer Stem Cells; Nanosized PS Delivery System; Nanocarriers; Active Targeting Delivery
资金
- National Natural Science Foundation of China [81372628]
- Natural Science Foundation of Hunan Province [12JJ5048]
- Planned Science and Technology Project of Hunan province [2014FJ6015, 2013WK3029, 2012FJ3129]
- Scientific Research Foundation from Public Health Department of Hunan Province [B2012-037]
- Changsha Science and Technology Plan [K1205018-31]
- Open-End Fund for the Valuable and Precision Instruments of Central South University [CSUZC2013035]
- DHS-DNDO-ARI program [2011-DN-077-ARI053-02, 2011-DN-077-ARI053-03, 2011-DN-077-ARI053-04, 2011-DN-077-ARI053-05]
- U.S. Army Medical Research Acquisition Activity (USAMRAA) [W81XWH-10-1-0279, W81XWH-10-1-0234]
Cancer stem cells are believed to be the basis for tumor initiation, development, metastasis and recurrence; are resistant to most traditional therapies (e.g., chemotherapy and radiotherapy); and have the ability to self-renew, proliferate and differentiate. Photodynamic therapy may be a promising novel treatment for drug-resistant cancer stem cells because of the selectivity of the photosensitizer. One of the most important issues to overcome in photodynamic therapy is the photosensitizer-targeted delivery to tumor cells, especially cancer stem cells. Nano-photosensitizers comprising molecular photosensitizers and water-dispersible nanocarriers with or without moieties possessing the ability for specific binding to cancer cells or cancer stem cells are a promising strategy for active targeted photosensitizer delivery and photodynamic therapy-targeted therapy of tumors. In this review, we highlight current and future prospects for potential strategies based on nanoscience and nanotechnology for nano-photosensitizer-targeted delivery in the photodynamic therapy treatment of cancer cells, especially cancer stem cells.
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