期刊
BIOCHEMICAL ENGINEERING JOURNAL
卷 7, 期 2, 页码 157-162出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1369-703X(00)00116-9
关键词
shaking bioreactor; oxygen transfer; bioprocess monitoring; respiration; bioreactor; fermentation
The oxygen transfer rate (OTR) is the most suitable measurable parameter to quantify the physiological state of a culture of aerobic microorganisms since most metabolic activities depend on oxygen consumption. Online measurement of the oxygen transfer rate in stirred bioreactors is state of the art although technically difficult. However, the online determination of the oxygen transfer rate in shaking bioreactors under sterile conditions has not been possible until recently. A newly developed measuring device eliminates this deficit. Extremely useful information about cultivating conditions and the physiological state of microorganisms can be gained in early stages of research and bioprocess development from many reactors operated in parallel. (C) 2001 Elsevier Science B.V. All rights reserved.
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