期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1810, 期 11, 页码 1080-1090出版社
ELSEVIER
DOI: 10.1016/j.bbagen.2011.01.012
关键词
Asthma; Viral infection; Influenza; 2009 H1N1 influenza; Rhinovirus; Bocavirus; Respiratory syncytial virus; Human metapneumovirus
资金
- National Institutes of Health [R01 HL090664, R01 AI070672, R01 AI059108, GM015431, R21 HL106446, UL1 RR024975]
- Department of Veteran Affairs [1I01BX000624]
Background: Viral respiratory infection has long been known to influence the occurrence of asthma exacerbations. Over the last 20 years much effort has been put into clarifying the role that viral respiratory infections play in the eventual development of asthma. Scope of review: In this review we give a general background of the role of viruses in the processes of asthma exacerbation and asthma induction. We review recent additions to the literature in the last 3 years with particular focus on clinical and epidemiologic investigations of influenza, rhinovirus, bocavirus, respiratory syncytial virus, and metapneumovirus. Major conclusions: The development of asthma emerges from a complex interaction of genetic predisposition and environmental factors with viral infection likely playing a significant role in the effect of environment on asthma inception. This article is part of a Special Issue entitled: Biochemistry of Asthma. General significance: Further understanding of the role that viruses play in asthma exacerbation and inception will contribute to decreased asthma morbidity in the future. This article is part of a Special Issue entitled: Biochemistry of Asthma. (C) 2011 Elsevier B.V. All rights reserved.
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