期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 29, 期 2, 页码 108-113出版社
CAMBRIDGE MED PUBL
DOI: 10.1177/147323000102900207
关键词
acute myocardial infarction; leptin; interleukin 6
We measured leptin concentrations in patients with acute myocardial infarction (AMI, n = 21) and in 15 age-matched controls, and compared leptin concentrations with levels of other myocardial enzymes and indicators of AMI. Blood was sampled immediately after hospital admission and at 1 h, 2 h, 3 h, 6 h and 9 h, then every 12 h until 5 days post-admission. Patients were stratified into three groups according to peak leptin concentrations: hypoleptinaemia (< 3 ng/ml); normoleptinaemia (greater than or equal to 3 - 15 ng/ml) and hyperleptinaemia (greater than or equal to 15 ng/ml). Hypoleptinaemic AMI patients had significantly increased concentrations of plasma lactate dehydrogenase compared with normoleptinaemic patients. No significant differences in other serum markers were noted between hyperleptinaemic and normoleptinaemic AMI patients. A significant negative correlation was found between the peak concentrations of leptin and interleukin 6. Leptin may play a role in the regulation of the development of cardiac damage in patients with AMI.
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