期刊
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
卷 11, 期 12, 页码 2231-2242出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbn.2015.2118
关键词
PAHy-Based Nanogel; Release Property Adhesion; Permeability Retention; Pharmacokinetic Study; Oral Administration; Paclitaxel
资金
- National Basic Research Program of China (973 Program) [2015CB932100]
- National Natural Science Foundation of China [81473165]
- Liaoning Provincial Key Laboratory of Drug Preparation Design and Evaluation of Liaoning Provincial Education Department [LZ2014045]
- Liaoning Provincial Key Laboratory of Studying the Modern Drug preparations
A family of nanogel drug carriers has been designed to enhance the oral absorption of paclitaxel (PTX). The PAHy-based nanogels were prepared by the interpenetration of poly-a,p-polyasparthydrazide (PAHy) chains and dicarboxyl-poly (ethylene glycol) (CPEG), forming a smart chain network. The PAHy-based nanogels were characterized by Fourier Transform Infrared Spectroscopy (FT-IR), dynamic light scattering (DLS), X-ray diffraction (XRD) and high performance liquid chromatography (HPLC). The adhesion and retention properties of fluorescein isothiocyanate (FITC)-nanogels in vivo were investigated using an in vivo imaging system and confocal laser scanning microscopy (CLSM). The smart nanogels had a particle size of similar to 200 nm, increased the degree and rate of release, and spent over 12 h in the gastrointestinal tract. They also produced excellent adhesion, permeability and retention (APR) effects and increased oral absorption, confirming their use as potential sustained-release carriers for the oral delivery of the hydrophobic anticancer agent PTX.
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