4.5 Review

Seed in soil, with an epigenetic view

期刊

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1790, 期 9, 页码 920-924

出版社

ELSEVIER
DOI: 10.1016/j.bbagen.2008.12.004

关键词

Breast cancer; Tumor microenvironment; Stromal fibroblast; Epigenetics; DNA methylation; Chromatin remodeling

资金

  1. NIH [U54CA113001, R01CA069065]
  2. American Cancer Society
  3. Department of Defense [BC073892]
  4. Susan G. Komen Breast Cancer Foundation [KG081123]

向作者/读者索取更多资源

it is becoming increasingly evident that discrete genetic alterations in neoplastic cells alone cannot explain multistep carcinogenesis whereby tumor cells are able to express diverse phenotypes during the complex phases of tumor development and progression. The epigenetic model posits that the host microenvironment exerts an initial, inhibitory constraint on tumor growth that is followed by acceleration of tumor progression through complex cell-matrix interactions. This review emphasizes the epigenetic aspects of breast cancer development in light of such interactions between epithelial cells (seed) and the tumor microenvironment (soil). Our recent research findings suggest that epigenetic perturbations induced by the tumor microenvironment may play a causal role in promoting breast cancer development. It is believed that abrogation of these initiators could offer a promising therapeutic strategy. (C) 2008 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据