期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1790, 期 10, 页码 1059-1066出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2009.04.005
关键词
Aging; Anti-aging; Caloric restriction; PGC-1 alpha; Mitochondrial dysfunction; Aging associated disease; Resveratrol
资金
- NIH/NIA [AG11915]
- NIH/NCRR/CFSA [UL1RR025011]
- NATIONAL CANCER INSTITUTE [P20CA103697] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025011] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P01AG011915] Funding Source: NIH RePORTER
Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction - a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1 alpha is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1 alpha is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1 alpha regulation and illustrate how these pathways may be involved in the aging process. Published by Elsevier B.V.
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